Burns. 2025 Nov 17;52(1):107787. doi: 10.1016/j.burns.2025.107787. Online ahead of print.

BACKGROUND: Burn survivors can experience overlapping symptoms; identifying clusters may improve care. This study examined chronic symptom clusters six months post-burn and their predictors and psychosocial impacts.

METHODS: Data from the Burn Model System (2015-2022) were analyzed using factor analysis of post-burn symptoms. Linear regression assessed associations between factor scores and psychosocial outcomes.

RESULTS: The sample included 405 patients (66 % male; mean age 45.4; median burn size 14 % TBSA; 60.2 % fire/flame). A three-factor solution was identified: (1) Psychological distress (28 % variance) with high loadings for anxiety and depression, moderate for sleep disturbance; (2) Pain-related symptoms (22 %) with high pain interference and intensity, moderate fatigue; (3) Itch-related symptoms (16 %) with high itch interference, moderate itch intensity. Rehabilitation days were associated with all factors; surgeries with Factors 1 and 2. Women scored higher on Factor 1, while %TBSA predicted Factor 3. Higher Factor 1 scores were linked to poorer mental health, greater PTSD burden, and lower life satisfaction and higher Factor 2 scores to worse physical and mental health.

CONCLUSION: At six months post-burn, symptoms clustered into psychological distress, pain, and itch factors. Pain and distress, but not itch, were associated with poorer physical, mental, and social functioning.

PubMed:41314038 | DOI:10.1016/j.burns.2025.107787