Cureus. 2025 Nov 9;17(11):e96431. doi: 10.7759/cureus.96431. eCollection 2025 Nov.

Intracranial lipomas are rare congenital anomalies that result from the abnormal development of meningeal tissues, causing the formation of fatty deposits within the intracranial cavity. The pericallosal region is the most frequent site where such lipomas are often associated with structural abnormalities of the corpus callosum. Although many cases remain clinically silent, symptomatic presentations can include seizures, headaches, cognitive impairment, or unusual neurobehavioral findings. We present the case of a 30-year-old woman who was evaluated in the emergency department after a motor vehicle accident, which was preceded by a transient loss of consciousness, presumed to be a seizure. Neuroimaging revealed a tubulonodular pericallosal lipoma associated with callosal dysgenesis.

PubMed:41376757 | PMC:PMC12688041 | DOI:10.7759/cureus.96431