J Burn Care Res. 2025 Dec 6:iraf223. doi: 10.1093/jbcr/iraf223. Online ahead of print.

In this review, we studied the significance of multi-omics techniques in understanding the complex processes after burns. Severe burns result in both temporary local pathophysiological changes and long-term, profound, and extensive pathophysiological abnormalities. The utilization of multi-omics approaches to identify novel treatment targets or clarify the molecular mechanisms underlying pathophysiological alterations related to burn injury has significant promise. This review encapsulates recent advancements in the utilization of omics approaches to elucidate pathophysiological alterations and biomarkers associated with inflammation, wound healing, and metabolic pathways after burn injuries, encompassing the genome, transcriptome, proteome, metabolome, and microbiome. An enhanced comprehension of the pathophysiological alterations and biomarkers associated with burn injuries can promote the creation of more efficacious and focused therapeutic approaches.

PubMed:41351871 | DOI:10.1093/jbcr/iraf223