Resusc%20Plus.%202025%20Nov%206;26:101154.%20doi:%2010.1016/j.resplu.2025.101154.%20eCollection%202025%20Nov.

JUSTIFICACIÓN:%20Electroencefalografía%20temprana%20(EEG),%20iniciada%20dentro de%2012%20h%20después%20del paro%20cardíaco,%20permite%20rel iable%20pronóstico%20en%20aproximadamente%2050%20%%20de%20comatosos%20pacientes.%20Suero%20biomarcadores%20mayo%20complemento%20temprano%2 0Predicción%20de%20resultados%20basada en EEG,%20particularmente%20en%20casos%20indeterminados.%20Evaluamos%20el%20potencial%20aditivo%20pro gnóstico%20valor%20de%20el%20suero%20biomarcadores%20neuronas específicas%20enolasa%20(NSE),%20neurofilamento%20ligero%20cadena%20(NfL),%20S1 00%20calcio%20unión%20proteína%20%CE%B2%20(S100B),%20y%20%20fosforilada%20tau%20(p-Tau%20181)%20cuando%20se combina%20con%2 0temprano%20EEG.

MÉTODOS:%20En%20este%20pilot%20estudio,%20nosotros%20analizamos%20suero%20biomarcador%20concentraciones%20en%20múltiples%20t ime%20puntos%20(<12 h, 24 h, 72 h, 7 days) post-CA in comatose out-of-hospital CA patients included in the ghrelin in coma (GRECO) trial. EEG recordings were visually evaluated at 12 and 24 h post-arrest. Neurological outcomes were assessed using the Cerebral Performance Category (CPC) score at 6 months, dichotomised into good (CPC 1-2) or poor (CPC 3-5).

RESULTADOS:%20A%20total%20de%2049%20pacientes%20fueron%20incluidos;%2024%20(49%20%)%20had%20a%20pobre%20neurologica l%20resultado%20en%206%20meses.%20Las concentraciones%20de%20biomarcador%20de suero%20fueron%20significativamente%20%20más altas en%20pacientes con mal resultado%20 %20dentro de%2024%20h%20post-CA.%20NfL%20logrado%20an%20AUC%20de%200.90,%20seguido%20por%20p-Tau181%20(AUC%200.81),%20S100B%20(AUC%20 0.80)%20y%20NSE%20(AUC%200.76)%20para%20pobre%20resultado%20neurológico%20en%2024%20h%20post-CA.%20En%2040%20pacientes%20con%20EEG,% 20NfL%20%3E%20100%20pg/mL%20reclasificado%20indeterminado%20casos%20as%20probable%20mal%20resultado,%20con%20%3E128%20pg/mL%20at%20cualquiera %20tiempo%20logrando%20100%20%%20especificidad,%20diferente%20otros%20biomarcadores.

SIGNIFICADO:%20NfL%20demostrado%20superior%20 pronóstico%20rendimiento%20comparado%20con%20otros%20suero%20biomarcadores.%20Nuestros%20hallazgos%20preliminares%20sugieren%20pronósticos%20agregados c%20valor%20de%20NfL%20cuando%20combinado%20con%20temprano%20EEG%20(12-24%20h),%20particularmente%20en%20pacientes%20con%20indeterminado%20 Hallazgos de EEG%20.

PubMed:41334151%20|%20PMC:PMC1 2666577%20|%20DOI:10.1016/j.resplu.2025.101154