Injury. 2025 Nov 26;57(2):112913. doi: 10.1016/j.injury.2025.112913. Online ahead of print.

BACKGROUND: The global rise in obesity presents a complex challenge in trauma care, characterized by the «Obesity Paradox.» This study aimed to evaluate the biomechanical protection hypothesis and its influence on initial injury severity and clinical outcome in severely injured patients.

METHODS: This retrospective study analyzed 1549 adult trauma patients (ISS≥9) divided into Non-Obese (NO, BMI<30) and Obese (OB, BMI≥30) cohorts. Primary endpoints included ISS, regional AIS scores, and mortality. Secondary endpoints included physiological burden (SAPS II) and resource utilization (LOS, ICU LOS). Group differences were analyzed and the independent effect of BMI on mortality, adjusting for Age, ISS, and ASA status assessed.

RESULTS: The OB cohort was significantly older and presented higher pre-existing comorbidity. Supporting the cushioning effect, OB patients exhibited a significantly lower overall ISS (p=0.035) and lower regional AIS scores for the Head/Neck (p=0.008) and Abdomen/Pelvis (p=0.036). OB patients suffered greater morbidity however, with higher SAPS II scores (p1.08, p<0.001), while BMI itself was not a significant independent predictor (OR1.036, p=0.119).

CONCLUSIONS: Our findings strongly suggest that the «Obesity Paradox» in major trauma is not a mere statistical anomaly, but a reproducible phenomenon with a distinct mechanistic explanation: Biomechanical protection which results in a lower ISS, neutralizes the increased physiological and comorbidity burden of the obese state.

PubMed:41319408 | DOI:10.1016/j.injury.2025.112913