J Vet Emerg Crit Care (San Antonio). 2025 Nov 28. doi: 10.1111/vec.70062. Online ahead of print.

OBJECTIVE: To describe the use of activated carbon hemoperfusion (HP) and hemodialysis (HD) to treat a meloxicam overdose in a dog.

CASE SUMMARY: A 2-year-old neutered male Basset Hound mix was presented for an accidental overdose of meloxicam of up to 5.5 mg/kg. The dog was asymptomatic on presentation with mild azotemia. In-series activated carbon HP and HD were performed. Fifteen blood volumes were processed over 207 min, resulting in an 87.5% decrease in the serum meloxicam concentration, with the greatest reduction occurring within the first hour of treatment. The dog developed self-limiting hematochezia but otherwise had no clinical concerns. Eight weeks after HP/HD treatment, follow-up bloodwork showed a relatively static, mild azotemia.

NEW OR UNIQUE INFORMATION: This is the first clinical report to describe the successful use of activated carbon HP and HD in veterinary medicine and the first to document the use of HP to treat meloxicam toxicosis.

PubMed:41313643 | DOI:10.1111/vec.70062